Bioinformatics at the CGB :: Projects
Curation Analysis Tool for Protein Alignments
Project Leader:
Mehmet Dalkilic
As the genomes of more organisms become fully sequenced,
there will be a greater opportunity to understand the function,
structure, and evolution of genes. Typically, experimental
biologists focus on a family of proteins whose apparent functions are
similar because of homology derived from multiple sequence
alignments. Mutant phenotypes can then be analyzed, for example, to
better understand what specific amino acid or set of amino acids are
important in the function of a protein. Although there are a large
number publicly available, protein specific repositories, e.g.,
PROSITE, UniProt, and Pfam, few tools exist for experimental
biologists that provide a means for managing and visualizing the
curation data of the protein families they study. From the guidance
of Dr. Peter Cherbas, Professor and Director of the CGB, along with
several other CGB researchers, we have developed and continue to
improve a novel system designed for experimental biologists, called
the Curation Alignment Tool for Protein Analysis (CATPA). This
system allows for the efficient and effective creation, storage,
management, and querying of experimentally curated protein families.
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